Buffalo looked the better side as they moved just a game behind their big rivals.
The Kansas City Chiefs' long unbeaten run finally came to an end at the hands of the Buffalo Bills in one of a number of statement wins in the NFL on November 17.
After 15 straight wins the defending Super Bowl champions were outplayed in Buffalo as the Bills deservedly ran out 30-21 winners.
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Right from intercepting Patrick Mahomes' first pass of the game, Buffalo looked the better side as they moved just a game behind their big rivals in the race for the AFC play-offs top seed.
Mahomes kept the Chiefs in it with three touchdown passes, but just as they threatened yet another escapology act Bills quarterback Josh Allen took the game into his own hands and settled it with a barnstorming 26-yard touchdown run.
That makes four straight regular season wins over the Chiefs for Buffalo, who have lost three play-off meetings between the sides in the past four years. This was a more controlled and complete performance than usual by the Bills, without Allen having to do everything by himself and a sixth successive victory takes them to nine wins and two losses.
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It was also a rare convincing defeat of Kansas City, their first by more than a score since October 2021, as they finished the weekend 9-1. Buffalo kept Mahomes' offence to a season-low 259 yards and scored 30 points against a Chiefs defence that had gone 30 games without conceding that many.